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BMED 3100 Notes Week 13

by: Ernest Butler

BMED 3100 Notes Week 13 BMED 3100 A

Ernest Butler
Georgia Tech
Systems Physiology
Mrs. Barker

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Hey guys! Here are the notes for week 13 that covered Renal Blood Flow and Clearance of renal physiology.
Systems Physiology
Mrs. Barker
Class Notes
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This page Class Notes was uploaded by Ernest Butler on Monday November 16, 2015. The Class Notes belongs to BMED 3100 A at Georgia Institute of Technology taught by Mrs. Barker in Summer 2015. Since its upload, it has received 23 views. For similar materials see Systems Physiology in Biomedical Sciences at Georgia Institute of Technology.

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Date Created: 11/16/15
Renal Physiology Slide Renal Blood Flow Regulation RBF Change in PressureResistance o Afferent amp Efferent Constriction of the Afferent Arteriole leads to o Decreased RPF o Decreased ch o Decrease in GFR Constriction of efferent arteriole leads to o Decrease in RPF 0 Increase in ch 0 Increase in GFR Slide Autoregulation of RBF Myogenic hypothesis 0 Increase in Pa 0 Activates stretchactivated Ca2 channels Mechanism 2 o Tubuloglomerularfeedback Increase Pa Increased RBF and GFR Constriction of afferent arterioles Slide True Renal Plasma Flow Fick Principle 0 No creation or destruction in an organ what goes in must go out o PAH entering kidney PAH leaving kidney PAH entering kidney RApAH x RPF PAH leaving kidney RVPAH x RPF UPAH x V Slide Measuring RBF RBF RPFlHct o 1Hct can also be represented as Plasma Slide Renal Clearance 0 Volume of plasma from which a substance is removed by the kidneys per unit time 0 Clearance of S Mass of S excreted per unit timePasma concentration of S 0 Where S denotes substance 0 Mass of S excreted per unit time urine concentration x urine ow GFR 0 Volume of uid ltered from plasma per unit time Slide Slide Slide Slide Slide Importance of Na Major cation of ECF Determines ECF volume 0 Plasma volume Blood volume Blood Pressure 0 Kidneys o Na excretion Na intake 0 sodium balance Excretion of less Na than intake ECF increased D increased blood volume D increased BP 0 sodium balance Excretion of more N than intake Decreased ECF D decreased blood volume D decreased BP Renal Handling of Na Ascending Limb and Distal convoluted tubule are impermeable to water Early Proximal Tubule quotHighest Priorityquot work Most essential solutes reabsorbed o Na glucose amino acids HCO3 Late Proximal Tubule ReninAngiotensinAldosterone Study slide will be on test 0 Decrease in ECF volume activates ReninAngiotensinAldosterone system as well as changes in arterial pressure Thick Ascending Limb Impermeable to water diluting segment Reabsorbs 25 of ltered Na by active transport Early Distal Tubule Reabsorbs 5 of ltered Na Impermeable to water 0 Cortical diluting segmentin kidney cortex 0 Further dilation


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