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Week 12 Notes (Chapters 13, 14)

by: Nausheen Zaman

Week 12 Notes (Chapters 13, 14) Bio 1510

Marketplace > Wayne State University > Biology > Bio 1510 > Week 12 Notes Chapters 13 14
Nausheen Zaman
GPA 3.3
(LS) Bas Life Mch
Dr. Nataliya Turchyn

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About this Document

chapters 13 and 14 notes, have a great thanksgiving break!!
(LS) Bas Life Mch
Dr. Nataliya Turchyn
Class Notes
25 ?




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This 11 page Class Notes was uploaded by Nausheen Zaman on Sunday November 22, 2015. The Class Notes belongs to Bio 1510 at Wayne State University taught by Dr. Nataliya Turchyn in Summer 2015. Since its upload, it has received 74 views. For similar materials see (LS) Bas Life Mch in Biology at Wayne State University.


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Date Created: 11/22/15
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DNA Synthesized o Phosphodiester bond forms between 5 phosphate groups of one sugar and 3 OH hydroxyl group of adjacent sugar 0 Linear strands of DNA have a free 5 phosphate group and free 3 OH hydroxyl group 3D Structure of DNA How is DNA Synthesized where s free 9 is attached 1390 the 539 C of one terminal Sugarphosphate backbone V whersd free OH is matched 1390 the 339 C of another terminal sugar 0 Rosalind Franklin and Maurice Wilkins I Xray diffraction studies suggested that DNA had helical shape of about 2 nanometers nm 0 James Watson and Francis Crick Figured out DNA was a double helix 2 strands of nucleotides Bases point inwards to for base pairs Purines paired with Pyrimidines I Strands antiparallel Base Pairing One strand runs 5 3 Opposite strand runs 3 5 o Pyrimidines always pair with purines o TAbond2Hbonds o CGbond3Hbonds DNA Replication Semiconservative 0 Parent DNA molecule unzips 0 Each parent DNA strand template for new daughter DNA strand I Confirmed by MeselsonStahl Experiment 0 DNA Replication Process 0 Replication of DNA begins at several specific site along DNA molecule origins of replicationreplication origins 0 DNA polymerase 3 works with other enzymes to generate DNA strands o Eukaryotes have many origins of replication 0 Prokaryotes only have ONE origin of replication Parental DNA V Flleplication duplex origin New f 39 39 l strands 39 J1EE TWQ daughter DNA duplexes H WFEJHQTM Mata HEW hc39 PhatHim rwmlmu Gaping339 39 Template Strand New Strand Fempil te Strand New Strand Sugar nhaaphaie a Hial ail a li i H DNA polymerase Iii 0 DNA Replication Fork 0 Leading and lagging strands gt make daughter leading and lagging strands 0 Without SSB singlestrand binding proteins parents strands come back together I SSBs keep them apart DNA Replication Fork Preventquot parent strands sops DNA from Twis ng om reforming a double helix 39 Bclamp lay neleosrng the Tensron slidingdam madam In double helix strand 7 3 Singlestrand 21m l mmmumu 5 7 binding protein 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Telomerase Keeping Telomeres Long Enough o Telomerase gt reverse transcriptase gt enzyme that reverses transcription I Transcription when DNA used to make RNA I Reverse transcription when RNA used to make DNA 0 Each linear chromosomes has two telomeres Winn EmmettBit Inc Fatimaion In remedyElven or E quot 39 wf39 f ii i T j i IIIIIIIr Synthesis by texl omeraae Telomerase x f Telnrnere extended by teiltomeraae quot a Template RNA i5 1 part of enzyme


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