New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

Lecture 15 Cell Biology

Star Star Star Star Star
1 review
by: MelLem

Lecture 15 Cell Biology BIOL 225

Marketplace > Simmons College > Biology > BIOL 225 > Lecture 15 Cell Biology
Simmons College
GPA 3.4

Preview These Notes for FREE

Get a free preview of these Notes, just enter your email below.

Unlock Preview
Unlock Preview

Preview these materials now for free

Why put in your email? Get access to more of this material and other relevant free materials for your school

View Preview

About this Document

Cell biology lecture 15, chapter 7 part of exam 2
Cell Biology
Dr. Lopilato
Class Notes
25 ?




Star Star Star Star Star
1 review
Star Star Star Star Star
Samuel Croteau

Popular in Cell Biology

Popular in Biology

This 3 page Class Notes was uploaded by MelLem on Thursday March 31, 2016. The Class Notes belongs to BIOL 225 at Simmons College taught by Dr. Lopilato in Fall 2016. Since its upload, it has received 20 views. For similar materials see Cell Biology in Biology at Simmons College.

Similar to BIOL 225 at Simmons College


Reviews for Lecture 15 Cell Biology

Star Star Star Star Star

-Samuel Croteau


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 03/31/16
Lecture 15 Cell Biology Chapter 7 Interactions between cells and their environments Cell – Cell Adhesive Interactions  Four distinct families of integral membrane proteins play a major role in mediating cell-cell adhesion. 1) selectins 2) certain members of the immunoglobulic superfamily (IgSF) 3) certain members of the integrin family, 4) Cadherins  They are important in development, metastasis and inflammation. Cell – cell Adhesive Interactions  Cadherins – integral membrane proteins  Certain members of the IgSF and Integrins  Selectins Selectins  Selectins are a family of membrane glycoproteins that bind to specific oligiosaccharides on the surfaces of neighboring cells  Lectin is a term for a compound that binds to specific carbohydrate groups.  Selectins have a small cytoplasmic segment, a single membrane-spanning domain and a large extracellular portion.  Three cell-specific selectin types: o E – Selectin – endotherlial cells o P – Selectin – platelets and endothelial cells o L – selectin – Leukocytes (white blood cells) Just have different carbohydrate groups attached The Immunoglobulin Super Family (IgSF)  Antibodies are immunoglobulin proteins with Ig domains, 70 -110 a.a. organized into a tightly folded structure  The human genome encodes 765 distinct Ig domains, making it the most abundant domain the human proteins.  These proteins are members of the immunoglobulin super family, and most are involved with mediating interactions of lymphocytes with cells required for an immune response. (Macrophages, Lymphocytes, and target cells)  2 membrane proteins and 2 cells interacting through these proteins Cadherins  Cadherins include 3 different types as well: o E – Cadherin – epithelial o N – Cadherin – Neural o P – Cadherin –Placental  Cadherins have a large extracellular segment, a single transmembrane segment, and a small cytoplasmic domain  The cytoplasmic domain is often associated with catenin proteins to tether the cadherins to the cytoskeleton and transmit signals  Calcium ions maintain the extracellular portion of each cadherin in a rigid conformation required for cell adhesion  Cadherins require calcium for a reaction. Interactions of cells with other cells  Cadherins may mediate dynamic changes in adhesive contacts needed for morphogenesis.  During embryonic development, cells can change from an epithelium to a mesenchyme or visa versa.  This epithelia mesnechymal transition (EMT) is found during mesoderm formation. Migrating mesenchymal cells with eventually give rise to medodermal tissues such as blood, muscle and bone. Cell Junctions  Anchoring cells to other cells – link epithelial cells together o Desmosomes o Adherens Junctions  Tight junctions – sealing the extracellular space  Cell communication o Gap junctions o Plasmodesmata Junctions for Communication  Gap junctions – animal cells o Made of connexin protein o Passage of ions o Communication o Gap junctions – protein molecules of about 1000 Daltons can go through gap junctions. o Defects in gap junctions can cause deafness, blindness, cardiac problems, nerve degeneration and skin abnormalities.  Plasmodemata – plant cells o Connect plant cells o Dilates for passage of macromolecules o Plasmodesmata - are cytoplasmic channels passing through cell walls of adjacent plant cells o Lined by the plasma membrane o Contain a central structure, the desmotubule o Dilate and up to 50 Kilo Daltons (50,000 Dalton) proteins can move through. o Both proteins and RNA (serving a signal molecule) move through plasmodesmata


Buy Material

Are you sure you want to buy this material for

25 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Allison Fischer University of Alabama

"I signed up to be an Elite Notetaker with 2 of my sorority sisters this semester. We just posted our notes weekly and were each making over $600 per month. I LOVE StudySoup!"

Steve Martinelli UC Los Angeles

"There's no way I would have passed my Organic Chemistry class this semester without the notes and study guides I got from StudySoup."


"Their 'Elite Notetakers' are making over $1,200/month in sales by creating high quality content that helps their classmates in a time of need."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.