Microbiology 101 Week 10 Lecture Notes
Microbiology 101 Week 10 Lecture Notes 101.0
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This 0 page Class Notes was uploaded by Isabel Markowski on Sunday November 22, 2015. The Class Notes belongs to 101.0 at University of Wisconsin - Madison taught by a professor in Fall 2015. Since its upload, it has received 36 views. For similar materials see General Microbiology in Microbiology at University of Wisconsin - Madison.
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Date Created: 11/22/15
Week 10 Microbiology Lecture Notes Host Response to Microbes The Immune System Overview Microbes overcome physiological and anatomical barriers to infection 0 Innate Immune System responds 496 hours after infection fast non speci c 0 Adaptive Immune System responds 96 hours after infection slower speci c 0 Humoral antibodymediated Immunity AMI 0 Cellular Immunity CMI Tissuelergans of Immune System 0 Blood 0 Lymphatic System vessels nodes tissues Lymph vessels drain tissues to lymph nodes Lymph nodes where immune cells interact Secondary lymphoid tissue 0 Red blood cells RBC white blood cells WBC platelets plasma WBC start in bone marrow stem cell 0 Can develop many different cells Myeloids or lymphoids Myeloids dendritic cell macrophage neutrophil or mast cell Lympoids B cell T cell or plasma cell 0 Bone Marrow and Thymus where immune cells developmature o Spleen lters blood and where immune cells interact o Anatomical barriers basic preformed defenses 0 Skin mucosal surfaces Physical barrier Produce antimicrobial substances 0 Immune cells underlie skin and mucosal surfaces Secretions include lysozyme degrades peptidoglycan Mucus traps microbes and is removed Normal microbiota prevent colonization Blood proteins complement system kill microbes Innate Immunity Nonspeci c response to damage 0 Always there fast 0 Major points 0 Pathogens pathogenderived molecules andor damage that produces products that can be recognized o Phagocytes recognize initiate response 0 In ammation results controls pathogens 1 Recognition of Pathogens Immune system cells produce Pattern Recognition Receptors PRRs or PRMs 0 Ex TollLike Receptors TLRs Microbes produce MicrobeAssociated Molecular Patterns MAMPS or PAMPS Lipopolysaccharide major MAMP Lipoteichoic acid cell wall gram Flagellin subunit of agella Peptidoglycan fragments Also fungal viral MAMPS OOOOO 2 Recodnition initiates Phadocvtosis Stimulates phagocytes to release cytokines secreted immune 3 In ammation Response Nonspeci c reaction to damageinfection Normal outcome of immune response 0 Limits growth of pathogen limits damage to host and repairs damage 0 Vasodilation slows blood owincreases local blood volume 0 Vascular Permeability allows entry of cells to tissue Structure changes allow uid protein and in ammatory cells to leave bloodenter tissue WBC in blood increases often used for diagnostics Process localized in ammation Systemic In ammation can lead to excessive immune response 0 Systemic In ammation Response Syndrome sepsis Rubor redness tumor swelling calor heat dolor pain Powerful good in small doses but can also damage host cells and Ussues Other Components of Innate Immunity Complement System Complement System set of proteins blood allpurpose Main proteins C1 through C9 Circulate in inactive state 0 Activated By antibodies classical pathway By microbes alternate pathway By mannose Iectin pathway Several Functions 0 Promote phagocytosis o Attract immune cells 0 Kill microbes directly MAC membrane attack complex assembles on pathogen surface 0 MAC complex forms pore on membrane transmembrane pore to leak out cell Microbicidal Opsonization better phagocytosis Phagocyte cells have receptor for C3 that39s on microbe binding physically closer for phagocytosis Thick capsule or gram cell structure microbes more dif cult to attack