Seminar week 1
Seminar week 1 119P
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This 2 page Class Notes was uploaded by Jamie Yang on Sunday April 3, 2016. The Class Notes belongs to 119P at University of California - Los Angeles taught by Prof Blair in Spring 2016. Since its upload, it has received 6 views. For similar materials see Emerging Topics in Neuroscience in Psychlogy at University of California - Los Angeles.
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Date Created: 04/03/16
Sex Differentiation in the Brain: A Whole Body Perspective 1. UCLA Brain Research Institute lab of Neuroendocrinology a. Jake Lusis 2. Charles H. Tom Sawyer a. Georgia State University b. Atlanta, GA, USA 3. How do you get the differences? 4. What are the differences doing for you? 5. Sex differences in the brain… a. depend on hormonedependent and hormoneindependent actions of sex chromosomes as well as on environmental influences b. may cause as well as prevent sex diff in physiology and behavior c. may explain sex differences in the vulnerability for behavioral and other disorders d. can only be understood from a wholebody perspective 6. First: how we get the differencespoint a a. males have higher vasopressinimmunoreactive projections in lateral septum b. male hormones must be present early in life c. Castrated animals at diff times after 1 day, 7 days, etc. i. found neonatal castration reduces density of AVP fibers in the lateral septum d. will only see male behavior later in life if treated with testosterone 7. Effects of Circulating Gonadal Hormones on Sex Diff in Vasopressin Innervation a. castrated male – looks like a female 8. no sry genes = females 9. sry genes = males 10. sex chr complements make a diff 11. also due to environment 12. vasopressin – offspring of mothers with high or low lvls of licking and care a. females 0 area with V1a receptor binding b. sex diff 13. point b – sex diff in brain cause and prevent sex diff in physiology and behavior 14. extreme sex diff in vasopressin innervation in prairie voles a. biggest sex diff in AVP fiber density in the lateral septum are s high b. but physically, it’s hard to tell the prarie voles apart c. after cohabitation, living together, the AVP fiber density, there is an oscillation o more and less vasopressin d. vasopressin is important for aggression e. more vasopressin, higher parental responsiveness 15. female voles, hormonal changes associated with pregnancy and parturition appear to introduce maternal behavior 16. X Inactivation a. Xist RNA on inactive X only see in the females b. condensed chromosomes from differentiated mouse cells c. a sex difference present in every brain cell 17. dual fxn of sex diff in the brain a. may induce sex diff in behaviors and other centrally regulated fxns i. aggressive behavior ii. sexual behavior 18. vasopression 1a receptor knockout has behavior phenotype in male but not female mice a. elevated plus maze b. light box c. center open field 19. vp and onset of play a. females play earlier and more vigorously than males b. females have no vp in amygdala at this age though c. males: vp and lvl of play behavior, perf correlation, more vp more lvl of play behavior 20. pt c: may explain sex diff in the vulnerability for behavioral and other disorders 21. pt d: can only be understood fr a whole body perspective a. CNS b. lots of factors leading to sex diff 22. Xist a. a sex diff is present in every cell body b. effect of hyponatremia on brain i. imbalanced water and sodium