a. What would be the major product of the reaction in if the alkane had reacted with Br 2 instead of with Cl 2 ? Disregard stereoisomers. b. What would be the anticipated percent yield of the major product?
Tubulin Polymerization and Depolymerization as a Chemotherapeutic Approach Combating Cancer By: Maryna Gregulich Chemistry 4000 December 1, 2015 Introduction Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers that associate to form a hollow cylindrical structures which involved in cell movement, intracellular organelle trafficking, and mitosis (10). In the context of oncologic diseases, the tubulin family of proteins is well-known as the target of the tubulin-binding chemotherapeutics, which suppress the dynamics of the mitotic spindle causing mitotic arrest and cell death by apoptosis. Importantly, the different shifts in microtubule stability as wel
