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A student is trying to determine the mechanism for a reaction that uses ATP to activate

Organic Chemistry | 7th Edition | ISBN: 9780321803221 | Authors: Paula Yurkanis Bruice ISBN: 9780321803221 462

Solution for problem 64 Chapter 25

Organic Chemistry | 7th Edition

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Organic Chemistry | 7th Edition | ISBN: 9780321803221 | Authors: Paula Yurkanis Bruice

Organic Chemistry | 7th Edition

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Problem 64

A student is trying to determine the mechanism for a reaction that uses ATP to activate a carboxylate ion, which then reacts with a thiol. If the carboxylate ion attacks the g -phosphorus of ATP, the reaction products are the thioester, ADP, and phosphate. However, whether it attacks the a -phosphorus or the b -phosphorus of ATP cannot be determined from the reaction products because the thioester, AMP, and pyrophosphate would be the products in both reactions. The mechanisms can be distinguished by a labeling experiment in which the enzyme, the carboxylate ion, ATP, and radioactively labeled pyrophosphate are incubated, and ATP is isolated. If the isolated ATP is radioactive, attack occurred on the a -phosphorus. If it is not radioactive, then attack occurred on the b -phosphorus. Explain these conclusions.

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VSEPR Valence Shell Electron Pair Repulsion Theory (VSEPR) is a qualitative theory that allows us to predict the geometry of molecules based upon their Lewis structures. This model looks at the repulsion of different electron regions (either bonding or non-bonding) and chooses a geometry that minimizes their repulsions. Valence Bond Theory The valence bond model is a quantum mechanical model for understanding bonding in molecules. However, now it is mostly used by chemists as a means to describe the bonding with organic systems qualitatively. The idea is that bonds form between atoms as a result of the overlap of atomic orbitals. This leads to what we would call a localized bonding picture. You can point to a bond in a molecule and say what types of atomic orbitals lead to that parti

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Chapter 25, Problem 64 is Solved
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Textbook: Organic Chemistry
Edition: 7
Author: Paula Yurkanis Bruice
ISBN: 9780321803221

This full solution covers the following key subjects: . This expansive textbook survival guide covers 354 chapters, and 1958 solutions. This textbook survival guide was created for the textbook: Organic Chemistry, edition: 7. Organic Chemistry was written by and is associated to the ISBN: 9780321803221. The full step-by-step solution to problem: 64 from chapter: 25 was answered by , our top Chemistry solution expert on 03/16/18, 03:38PM. The answer to “A student is trying to determine the mechanism for a reaction that uses ATP to activate a carboxylate ion, which then reacts with a thiol. If the carboxylate ion attacks the g -phosphorus of ATP, the reaction products are the thioester, ADP, and phosphate. However, whether it attacks the a -phosphorus or the b -phosphorus of ATP cannot be determined from the reaction products because the thioester, AMP, and pyrophosphate would be the products in both reactions. The mechanisms can be distinguished by a labeling experiment in which the enzyme, the carboxylate ion, ATP, and radioactively labeled pyrophosphate are incubated, and ATP is isolated. If the isolated ATP is radioactive, attack occurred on the a -phosphorus. If it is not radioactive, then attack occurred on the b -phosphorus. Explain these conclusions.” is broken down into a number of easy to follow steps, and 131 words. Since the solution to 64 from 25 chapter was answered, more than 225 students have viewed the full step-by-step answer.

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A student is trying to determine the mechanism for a reaction that uses ATP to activate