The first step in the biological degradation of lysine is reductive amination with

Chapter 26, Problem 26.61

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The first step in the biological degradation of lysine is reductive amination with a-ketoglutarate to give saccharopine. Nicotinamide adenine dinucleotide phosphate (NADPH), a relative of NADH, is the reducing agent. Show the mechanism. Saccharopine O2C N CO2 H H NH3 + Lysine O2C H H2N CO2 H NH3 + -Ketoglutarate

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