Solved: Fatty acids are synthesized by a multistep route that starts with acetate. The

Chapter 27, Problem 27.49

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Fatty acids are synthesized by a multistep route that starts with acetate. The first step is a reaction between protein-bound acetyl and malonyl units to give a protein-bound 3-ketobutyryl unit. Show the mechanism, and tell what kind of reaction is occurring. Malonylprotein O C C H H O O C S Protein Acetylprotein H3C O + C S Protein H3C C C H CO2 O O C S Protein 3-Ketobutyrylprotein H3C C C H H O O C + CO2 S Protein

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