In Section 10.12, we saw that S-adenosylmethionine (SAM) methylates the nitrogen atom of
Chapter 10, Problem 64(choose chapter or problem)
In Section 10.12, we saw that S-adenosylmethionine (SAM) methylates the nitrogen atom of noradrenaline to form adrenaline, a more potent hormone.If SAM methylates an OH group attached to the benzene ring instead, it completely destroys noradrenalines activity.a. Show the mechanism for the methylationof the OH group by SAM.b. Which reaction is more apt to occur, methylation on nitrogen or methylation on oxygen?
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