For each value of Ka, calculate the corresponding value of pKa. Which compoundis the

Melanie LeMay CHEM 224­L­01 H NMR – Proton Nuclear Resonance Spectroscopy Purpose: The purpose of H NMR also commonly known Proton NMR is to deduce the structure of the molecule using peaks containing multiplicity. Theory: NMR is an analytical tool used to help deduce the structure of organic molecules. It uses the chemical shift, integration, and multiplicity of neighboring protons to help determine which structure is best. NMR can be used for this reason due to the spin state of the nuclei of the proton. HNMR detects the carbon­hydrogen framework of an organic compound. The machine works by applying a magnetic field that orientates the atomic nucleus. There are two possible spin states for the H atom, when performing the HNMR, one can gain the knowledge of how many different H signals are present, the location from the type of protons, the integration given to you from the area under each signal that shows as a peak, and by gaining the shape or the multiplicity, one is able to know the amount of neighboring protons. Procedure: Creating A Solution: 1. The solution must be diluted, 4­20 mg of the sample may be used. The sample can be placed in a small clear vial, eppindorf or testtube. 2. Add 0.5­0.7 mL of the appropriate deuterated solvent. 3. Agitate the mixture in the vial. Ensure that the solution is homogenous. If there are any solids, they can be filtered with a glass wool plug. 4. Using a Pasteur pipet, transfer the sample to the NMR tube