A carboxylic acid has two oxygen atoms, each with two nonbonding pairs of electrons. (a) Draw the resonance forms of a carboxylic acid that is protonated on the hydroxyl oxygen atom. (b) Compare the resonance forms with those given previously for an acid protonated on the carbonyl oxygen atom. (c) Explain why the carbonyl oxygen atom of a carboxylic acid is more basic than the hydroxyl oxygen.
April 12, 2016 Clicker Question: Clicker Question: Bypass 1: takes pyruvate and adds carboxyl group to it. Spend ATP to do this Need biotin, amid bond COO- is added to methyl group on pyruvate kick CO2 off when making PEP (favorable) Bypass 2: hydrolysis reaction Bypass 3: is not going to happen except maybe in liver gluconeogenesis: favorable, negative free energy change reversal of glycolysis: unfavorable The Cori Cycle came from Eastern Europe, husband and wife sprinting: glycolysis in skeletal muscle functioning anaerobically Lactate goes to gluconeogenesis in liver Froctose-2,6-biphosphate - allosteric activator Excess consumption o