A step in a synthesis of PGE1 (prostaglandin E1,
Chapter 18, Problem 18.38(choose chapter or problem)
A step in a synthesis of PGE1 (prostaglandin E1, alprostadil) is the reaction of a trisubstituted cyclohexene with bromine to form a bromolactone. Propose a mechanism for formation of this bromolactone and account for the observed stereochemistry of each substituent on the cyclohexane ring. many steps O A bromolactone PGE1 (Alprostadil) Alprostadil is used as a temporary therapy for infants born with congenital heart defects that restrict pulmonary blood flow. It brings about dilation of the ductus arteriosus, which in turn increases blood fl ow in the lungs and blood oxygenation.
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