As discussed in Chemical Connections: Vitamin K, Blood

Chapter 27, Problem 27.2

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As discussed in Chemical Connections: Vitamin K, Blood Clotting, and Basicity in Section 26.6D, vitamin K participates in carboxylation of glutamic acid residues of the blood-clotting protein prothrombin. (a) Write a structural formula for g-carboxyglutamic acid. (b) Account for the fact that the presence of g-carboxyglutamic acid escaped detection for many years; on routine amino acid analyses, only glutamic acid was detected.

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