Following is the primary structure of glucagon, a

Chapter 27, Problem 27.44

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Following is the primary structure of glucagon, a polypeptide hormone of 29 amino acids. Glucagon is produced in the a-cells of the pancreas and helps maintain blood glucose levels in a normal concentration range. His-Ser-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg- Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr 1 5 10 15 20 25 29 Which peptide bonds are hydrolyzed when this polypeptide is treated with each reagent? (a) Phenyl isothiocyanate (b) Chymotrypsin (c) Trypsin (d) BrCN

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