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Atkins' Physical Chemistry | 11th Edition | ISBN: 9780198769866 | Authors: Atkins, Peter; De Paula, Julio; Keeler, James ISBN: 9780198769866 2042

Solution for problem P14E.1 Chapter 14E

Atkins' Physical Chemistry | 11th Edition

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Atkins' Physical Chemistry | 11th Edition | ISBN: 9780198769866 | Authors: Atkins, Peter; De Paula, Julio; Keeler, James

Atkins' Physical Chemistry | 11th Edition

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Problem P14E.1

The binding of nonpolar groups of amino acid to hydrophobic sites in the interior of proteins is governed largely by hydrophobic interactions.

(a) Consider a family of hydrocarbons R-H. The hydrophobicity constants, \(\pi\), for \(\mathrm{R}=\mathrm{CH}_{3}\), \(\mathrm{CH}_{2} \mathrm{CH}_{3}\),\(\left(\mathrm{CH}_{2}\right)_{2} \mathrm{CH}_{3}\),\(\left(\mathrm{CH}_{2}\right)_{3} \mathrm{CH}_{3}\), and \(\left(\mathrm{CH}_{2}\right)_{4} \mathrm{CH}_{3}\) are, respectively, 0.5,1.0,1.5,2.0, and 2.5. Use these data to predict the \(\pi\) value for \(\left(\mathrm{CH}_{2}\right)_{6} \mathrm{CH}_{3}\).

(b) The equilibrium constants \(K_{I}\) for the dissociation of inhibitors (6) from the enzyme chymotrypsin were measured for different substituents R:

                       

Plot \(\log K_{I}\) against \(\pi\). Does the plot suggest a linear relationship? If so, what are the slope and intercept to the \(\log K_{I}\) axis of the line that best fits the data?

(c) Predict the value of \(K_{\mathrm{I}}\) for the case R=H.

                                                     

Text Transcription:

pi

R=CH_3

CH_2 CH_3

(CH_2)_2 CH_3

(CH_2)_3 CH_3

(CH_2)_4 CH_3

(CH_2)_6 CH_3

K_I

log K_I

Step-by-Step Solution:
Step 1 of 3

o*2 c lo-* = (O,lO)(35,nr_) - o 'Ornl t35.s x] *d 5l Z" * ""4 il*s -- ,^2v ,r wt* Lrt h t &r *- * L 4 nro "*z{0"t--n*{-il"* = {oq}* (

Step 2 of 3

Chapter 14E, Problem P14E.1 is Solved
Step 3 of 3

Textbook: Atkins' Physical Chemistry
Edition: 11
Author: Atkins, Peter; De Paula, Julio; Keeler, James
ISBN: 9780198769866

The full step-by-step solution to problem: P14E.1 from chapter: 14E was answered by Aimee Notetaker, our top Chemistry solution expert on 04/25/22, 03:45PM. Since the solution to P14E.1 from 14E chapter was answered, more than 201 students have viewed the full step-by-step answer. The answer to “?The binding of nonpolar groups of amino acid to hydrophobic sites in the interior of proteins is governed largely by hydrophobic interactions.(a) Consider a family of hydrocarbons R-H. The hydrophobicity constants, \(\pi\), for \(\mathrm{R}=\mathrm{CH}_{3}\), \(\mathrm{CH}_{2} \mathrm{CH}_{3}\),\(\left(\mathrm{CH}_{2}\right)_{2} \mathrm{CH}_{3}\),\(\left(\mathrm{CH}_{2}\right)_{3} \mathrm{CH}_{3}\), and \(\left(\mathrm{CH}_{2}\right)_{4} \mathrm{CH}_{3}\) are, respectively, 0.5,1.0,1.5,2.0, and 2.5. Use these data to predict the \(\pi\) value for \(\left(\mathrm{CH}_{2}\right)_{6} \mathrm{CH}_{3}\). (b) The equilibrium constants \(K_{I}\) for the dissociation of inhibitors (6) from the enzyme chymotrypsin were measured for different substituents R: Plot \(\log K_{I}\) against \(\pi\). Does the plot suggest a linear relationship? If so, what are the slope and intercept to the \(\log K_{I}\) axis of the line that best fits the data?(c) Predict the value of \(K_{\mathrm{I}}\) for the case R=H. Text Transcription:piR=CH_3CH_2 CH_3(CH_2)_2 CH_3(CH_2)_3 CH_3(CH_2)_4 CH_3(CH_2)_6 CH_3K_Ilog K_I” is broken down into a number of easy to follow steps, and 128 words. This textbook survival guide was created for the textbook: Atkins' Physical Chemistry, edition: 11. This full solution covers the following key subjects: . This expansive textbook survival guide covers 327 chapters, and 1120 solutions. Atkins' Physical Chemistry was written by Aimee Notetaker and is associated to the ISBN: 9780198769866.

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