?The reaction that follows is catalyzed by isocitrate dehydrogenase and occurs in two

Chapter 21, Problem 21.24

(choose chapter or problem)

The reaction that follows is catalyzed by isocitrate dehydrogenase and occurs in two steps, the first of which (step A) is formation of an unstable intermediate (shown in brackets).

(a) In which step is a coenzyme needed? Identify the coenzyme.

(b) In which step is \(\mathrm{CO}_{2}\)evolved and a hydrogen ion added?

(c) Which of the structures shown can be described as a \(\beta\)-keto acid?

(d) To what class of enzymes does isocitrate dehydrogenase, the enzyme that catalyzes this reaction, belong?

Text Transcription:

B

CO_2

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