Show how you would synthesize the following primary alcohols by adding an appropriate Grignard reagent to formaldehyde.
Here, we are going to propose the mechanism for the synthesize the following primary alcohols by adding an appropriate Grignard reagent to formaldehyde.
The organomagnesium halides, of empirical formula R-Mg-X are called Grignard reagents by the name of French chemist Victor Grignard. Grignard reagents can be obtained from the reaction of an alkyl halide with magnesium metal in presence of dry (anhydrous) ether solvent, which is needed to solvate and stabilize the Grignard reagent as it forms.
R-X + Mg → R-Mg-X
Grignard reagent has been used for the synthesis of alcohol.
Step 1: Grignard reagent reagent attacks the carbonyl carbon of the formaldehyde
Step2: Water or dilute acid is added to protonate the alkoxide and give the alcohol.