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Show two ways you could synthesize each of the following
Chapter 2, Problem 14P(choose chapter or problem)
Show two ways you could synthesize each of the following secondary alcohols by adding an appropriate Grignard reagent to an aldehyde.
Equation Transcription:
Text Transcription:
OH
OH
H
C
OH
Questions & Answers
QUESTION:
Show two ways you could synthesize each of the following secondary alcohols by adding an appropriate Grignard reagent to an aldehyde.
Equation Transcription:
Text Transcription:
OH
OH
H
C
OH
ANSWER:
Solution 14P:
Here, we are going to propose the mechanism for the synthesize the following secondary alcohols by adding an appropriate Grignard reagent to aldehyde.
The organomagnesium halides, of empirical formula R-Mg-X are called Grignard reagents by the name of French chemist Victor Grignard. Grignard reagents can be obtained from the reaction of an alkyl halide with magnesium metal in presence of dry (anhydrous) ether solvent, which is needed to solvate and stabilize the Grignard reagent as it forms.
R-X + Mg → R-Mg-X
Grignard reagent has been used for the synthesis of alcohol.
(a)
Step 1: Grignard reagent reagent attacks the carbonyl carbon of the aldehyde to form alkoxide
Step2: the alkoxide is protonated by using water or dilute acid to give the alcohol.
Or