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Introductory Chemistry | 5th Edition | ISBN: 9780321910295 | Authors: Nivaldo J Tro
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Sickle-cell anemia is caused by a genetic defect that sub­stitutes valine for glutamic

Chapter 19, Problem 92P

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QUESTION:

Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the hemoglobin protein. The result is a decrease in the water solubility of hemoglobin. Examine the structures of valine and glutamic acid in Table \(19.2\) and

explain why this might be so.

Equation Transcription:

Text Transcription:

19.2

Questions & Answers

QUESTION:

Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the hemoglobin protein. The result is a decrease in the water solubility of hemoglobin. Examine the structures of valine and glutamic acid in Table \(19.2\) and

explain why this might be so.

Equation Transcription:

Text Transcription:

19.2

ANSWER:

Solution:

Step 1

Sickle cell anemia is caused by a genetic defect that substitutes valine for glutamic acid in a specific position in the hemoglobin protein. The structure of the two amino acids are,

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