Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the hemoglobin protein. The result is a decrease in the water solubility of hemoglobin. Examine the structures of valine and glutamic acid in Table 19.2 and
explain why this might be so.
Sickle cell anemia is caused by a genetic defect that substitutes valine for glutamic acid in a specific position in the hemoglobin protein. The structure of the two amino acids are,