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Answer: Determining the amino acid sequence in a protein usually involves treating the

Introductory Chemistry | 5th Edition | ISBN: 9780321910295 | Authors: Nivaldo J Tro ISBN: 9780321910295 34

Solution for problem 85P Chapter 19

Introductory Chemistry | 5th Edition

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Introductory Chemistry | 5th Edition | ISBN: 9780321910295 | Authors: Nivaldo J Tro

Introductory Chemistry | 5th Edition

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Problem 85P

Problem 85P

Determining the amino acid sequence in a protein usually involves treating the protein with various reagents that break up the protein into smaller fragments, which can be individually sequenced. Treating a particular 11-amino-acid polypeptide with one reagent produced these fragments:

trp-glu-val, gly-arg, ala-ser-phe-gly-asn-lys

Treating the same polypeptide with a different reagent produced the following fragments:

gly-asn-lys-trp, glu-val, gly-arg-ala-ser-phe

What is the amino acid sequence of the polypeptide?

Step-by-Step Solution:
Step 1 of 3

Answer :

The amino acid sequence of acylphosphatase from porcine skeletal muscle was determined. It consists of 98 amino acid residues with N-acetylserine at the amino (N)-terminus: Ac-Ser-Thr-Ala-Arg-Pro-Leu-Lys-Ser-Val-Asp-Tyr-Glu-Val-Phe-Gly -Arg-Val-Gln-Gly-Val-Cys-Phe-Arg-Met-Tyr-Thr-Glu-Asp-Glu-Ala-Arg-Lys-Ile -Gly-Val-Val-Gly-Trp-Val-Lys-Asn-Thr-Ser-Lys-Gly-Thr-Val-Thr-Gly-Gln -Val-Gln-Gly-Pro-Glu-Glu-Lys-Val-Asn-Ser-Met-Lys-Ser-Trp-Leu-Ser-Lys -Ile-Gly-Ser-Pro-Ser-Ser-Arg-Ile-Asp-Arg-Thr-Asn-Phe-Ser-Asn-Glu-Lys- Thr-Ile-Ser-Lys-Leu-Glu-Tyr-Ser-Asn-Phe-Ser-Ile-Arg-Tyr-OH. This sequence has three substitutions of amino acid residues, i.e., Thr/Ala, Ile/Val, and Ile/Val at positions 26, 68, and 96, respectively, from that of horse muscle acylphosphatase, formerly the only mammalian acylphosphatase with known sequence.

Step 2 of 3

Chapter 19, Problem 85P is Solved
Step 3 of 3

Textbook: Introductory Chemistry
Edition: 5
Author: Nivaldo J Tro
ISBN: 9780321910295

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