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Solved: The following compound has been found to be an

Chapter 16, Problem 92P

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QUESTION:

The following compound has been found to be an inhibitor of penicillinase. The enzyme can be reactivated by hydroxylamine \(\left(\mathrm{NH}_{2} \mathrm{OH}\right)\). Propose a mechanism to account for the inhibition and for the reactivation.

Equation Transcription:

(NH2OH)

Text Transcription:

(NH_2OH)

Questions & Answers

QUESTION:

The following compound has been found to be an inhibitor of penicillinase. The enzyme can be reactivated by hydroxylamine \(\left(\mathrm{NH}_{2} \mathrm{OH}\right)\). Propose a mechanism to account for the inhibition and for the reactivation.

Equation Transcription:

(NH2OH)

Text Transcription:

(NH_2OH)

ANSWER:

Solution  92P

 Given Compound

Inhibition

When the given compound is found to be an inhibitor of penicillinase the compound is converted to acid and the amino group

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