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The deuterium kinetic isotope effect (kH2O/kD2O) for the

Chapter 23, Problem 34P

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QUESTION:

Problem 34P

The deuterium kinetic isotope effect (kH2O/kD2O) for the hydrolysis of aspirin is 2.2. What does this tell you about the kind of catalysis exerted by the ortho-carboxyl substituent? (Hint: It is easier to break an O-H bond than an O-D bond.)

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QUESTION:

Problem 34P

The deuterium kinetic isotope effect (kH2O/kD2O) for the hydrolysis of aspirin is 2.2. What does this tell you about the kind of catalysis exerted by the ortho-carboxyl substituent? (Hint: It is easier to break an O-H bond than an O-D bond.)

ANSWER:

Solution 34P

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