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In the article “Assessment of Dermatopharmacokinetic

Statistics for Engineers and Scientists | 4th Edition | ISBN: 9780073401331 | Authors: William Navidi ISBN: 9780073401331 38

Solution for problem 8E Chapter 4.10

Statistics for Engineers and Scientists | 4th Edition

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Statistics for Engineers and Scientists | 4th Edition | ISBN: 9780073401331 | Authors: William Navidi

Statistics for Engineers and Scientists | 4th Edition

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1
Problem 8E

In the article “Assessment of Dermatopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products” (L. Pershing, J. Nelson, et al., Journal of the American Academy of Dermatology, 2003:740-751), measurements of the concentration of an anti-fungal gel, in ng per square centimeter of skin, were made one hour after application for 49 individuals. Following are the results. The authors claim that these data are well-modeled by a lognormal distribution. Construct an appropriate probability plot, and use it to determine whether the data support this claim.

132.44

76.73

258.46

177.46

73.01

130.62

235.63

107.54

75.95

70.37

88.76

104.00

19.07

174.30

82.87

68.73

41.47

120.44

136.52

82.46

67.04

96.92

93.26

72.92

138.15

82.43

245.41

104.68

82.53

122.59

147.12

129.82

54.83

65.82

75.24

135.52

132.21

85.63

135.79

65.98

349.71

77.84

89.19

102.94

166.11

168.76

155.20

44.35

202.51

Step-by-Step Solution:

Step 1 of 1:

Given, the measurement of the concentration of an anti-fungal gel, in ng per square centimeter of skin, were made one hour after application for 49 individuals.  

We know that the data are well-modeled by a lognormal distribution.

Here Ylognormal distribution with the parameters mean  and standard deviation .

So YN.

Our goal is:

We need to construct an appropriate probability plot, and use it to determine whether the data support this claim.

Now we need to construct an appropriate probability plot, and use it to determine whether the data support this claim.

We have to use this formula to compute the pairs.

(In,)

Where i=1,2,3,...,n and

The natural logs of the ordered observation = In.

Then the table is given below.

...

i

In

i

Step 2 of 3

Chapter 4.10, Problem 8E is Solved
Step 3 of 3

Textbook: Statistics for Engineers and Scientists
Edition: 4
Author: William Navidi
ISBN: 9780073401331

The answer to “In the article “Assessment of Dermatopharmacokinetic Approach in the Bioequivalence Determination of Topical Tretinoin Gel Products” (L. Pershing, J. Nelson, et al., Journal of the American Academy of Dermatology, 2003:740-751), measurements of the concentration of an anti-fungal gel, in ng per square centimeter of skin, were made one hour after application for 49 individuals. Following are the results. The authors claim that these data are well-modeled by a lognormal distribution. Construct an appropriate probability plot, and use it to determine whether the data support this claim.132.4476.73258.46177.4673.01130.62235.63107.5475.9570.3788.76104.0019.07174.3082.8768.7341.47120.44136.5282.4667.0496.9293.2672.92138.1582.43245.41104.6882.53122.59147.12129.8254.8365.8275.24135.52132.2185.63135.7965.98349.7177.8489.19102.94166.11168.76155.2044.35202.51” is broken down into a number of easy to follow steps, and 86 words. The full step-by-step solution to problem: 8E from chapter: 4.10 was answered by , our top Statistics solution expert on 06/28/17, 11:15AM. This textbook survival guide was created for the textbook: Statistics for Engineers and Scientists , edition: 4. Since the solution to 8E from 4.10 chapter was answered, more than 371 students have viewed the full step-by-step answer. This full solution covers the following key subjects: gel, dermatopharmacokinetic, data, claim, Academy. This expansive textbook survival guide covers 153 chapters, and 2440 solutions. Statistics for Engineers and Scientists was written by and is associated to the ISBN: 9780073401331.

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