Quaternary structures of proteins arise if two or more
Chapter , Problem 1DE(choose chapter or problem)
Problem 1DE
Quaternary structures of proteins arise if two or more smaller polypeptides or proteins associate with each other to make a much larger protein structure. The association is due to the same hydrogen bonding, electrostatic, and dispersion forces we have seen before. Hemoglobin, the protein used to transport oxygen molecules in our blood, is an example of a protein that has quaternary structure. Hemoglobin is a tetramer. it is made of four smaller polypeptides, two alphas' and two betas ' (These names do not imply anything about the number of alpha-helices or beta sheets in the individual polypeptides.) Design a set of experiments that would provide sound evidence that hemoglobin exists as a tetramer and not as one enormous polypeptide chain.
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