Show how you would use a Suzuki reaction to synthesize the following biaryl compound. As starting materials you may use the two indicated compounds, plus any additional reagents you need.
Here we have to synthesize the following biaryl compound by using Suzuki reaction .
The Suzuki reaction is also known as coupling reaction, in which the coupling partners are a boronic acid and an organohalide catalyzed by a palladium(0) complex.
R1-BY2 + R2X R1-R2 + BY2X
(boronic acid) (organo halide)
The mechanism of the Suzuki reaction has been carried out in presence of base and palladium as a catalyst.
The first step is the oxidative addition of palladium to the halide 2 to form the organopalladium species 3. Reaction with base gives intermediate 4, which via transmetalation with the boron-ate complex 6 (produced by reaction of the boronic acid 5 with base) forms the organopalladium species 8. Reductive elimination of the desired product 9 restores the original palladium catalyst 1 which completes the catalytic cycle.