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The antibiotic gentamicin sulphate is often blended with

Statistics for Engineers and Scientists | 4th Edition | ISBN: 9780073401331 | Authors: William Navidi ISBN: 9780073401331 38

Solution for problem 4E Chapter 9.1

Statistics for Engineers and Scientists | 4th Edition

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Statistics for Engineers and Scientists | 4th Edition | ISBN: 9780073401331 | Authors: William Navidi

Statistics for Engineers and Scientists | 4th Edition

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Problem 4E

The antibiotic gentamicin sulphate is often blended with acrylic bone cement to help prevent infection following joint replacement surgery. The article “Incorporation of Large Amounts of Gentamicin Sulphate Into Acrylic Bone Cement: Effect on Handling and Mechanical Properties, Antibiotic Release, and Biofilm Formation” (N. Dunne, P. McAfee, et al., Journal of Engineering in Medicine, 2008:355-365) presents a study of the effect of the amount of antibiotic added on various properties of the cement. Following are measurements of the setting time of the cement, for six levels of antibiotic amount, and three replications per level. The measurements are consistent with means and standard deviations presented in the article.

a. Construct an ANOVA table. You may give a range for the P-value.

b. Can you conclude that there are differences among the mean setting times?

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Chapter 20 What is the difference between narrow­ and broad­spectrum antibiotics When are each prescribed and what are the consequences of each Narrow spectrum antibiotics Consequences ­ only kills microbe causing infection When ­ If you know the microbe causing infection ­ patient is not seriously sick Broad spectrum antibiotics Consequences ­ you can kill many microbes at once ­ affect normal microbes of the patient When ­ If the patient is gravely ill ­ cause of infection is not known What are the five major ways that an antibiotic acts on a bacterial cell Identify modes of action of the following antimicrobial drugs; a. inhibition of cell wall synthesis ­Beta­lactams (natural penicillins, semisynthetic penicillins) b. inhibition of protein synthesis (these drugs target the prokaryotic ribosomes and eukaryotic mitochondrial ribosome specifically) ­streptomycin ­tetracycline ­chloramphenicol c. inhibition of metabolic pathways ­sulfonamides affect synthesis of folic acid (a precursor for DNA/RNA by competitive inhibition) d. inhibition of nucleic acid synthesis ­Quinolones (like cipro) Describe characteristics you should consider when selecting an antibiotic to treat a disease: a. efficacy (Minimum Inhibitory Concentration MIC/Minimum Bactericidal Concentration MBC) b. route of administration c. safety – toxicity (therapeutic index), allergies, disruption of normal microbiota, side effects d. Cost e. chemical stability What is the difference between bactericidal/bacteriostatic How are the MIC and MBC determined experimentally Bactericidal: kills all microbes Bacteriostatic: inhibits the growth of microbes How do bacteria resist antimicrobial drugs ­Beta­lactamase ­entry of the drug ­efflux pumps ­synergism How do we prevent the spread of antibiotic resistant bacteria Chapter 14 Define pathology, etiology, infection, and disease. ● Pathology­ concerned with interactions between host and pathogen ● Infection­ the ability of an agent to enter, survive and multiply in the host. ● Disease­ occurs when the infectious agent actually causes symptoms, and the body is no longer able to function normally ● Etiology­ what causes the disease Compare commensalism, mutualism, and parasitism. ● Commensalism: one organism benefits and the other is unaffected. ● Mutualism: both organisms benefit ● Parasitism: one organism benefits at the expense of the other List Koch’s postulates. Explain some exceptions to Koch’s postulates. ● The bacterium must be present in every case of the disease ● The bacterium must be isolated from the diseased host and grown in pure culture ● The specific disease must be reproduced when a pure culture of the bacterium is inoculated into a healthy susceptible host ● The bacterium must be recoverable from the experimentally infected host. Exceptions ● Some pathogens can’t be cultured ● Some diseases can involve any number of several pathogens ● Some pathogens can cause several diseases ● Ethically, you can’t re­inoculate a human to prove a microbe causes a disease ● Some humans have microbes but no disease Describe the importance of normal microbiota and microbial antagonism. How do normal microbiota become opportunistic pathogens Normal microbiota protect the host via microbial antagonism ● Microbial antagonism­ where microbes compete with one another for an ecological niche ● Opportunistic pathogens­ normal microbiota that cause disease under certain circumstances. 1. Immune suppression 2. Changes in normal microbiota 3. Introduction to new site Put the following in proper sequence according to the normal pattern of disease progression: period of decline, period of convalescence, period of illness, prodromal period, incubation period. 1. Incubation period 2. Prodromal period 3. Period of illness 4. Period of decline 5. Period of convalescence Define reservoir of infection. Contrast human, animal, and nonliving reservoirs, and give one example of each. Reservoir: the ecological niche of the pathogen that provides a continual source of infection Human: those that have the disease or those that carry the disease­causing pathogen but do not have symptoms of the disease ­ Example: salmonella typhi Animal: animals that can also carry a pathogen and transmit that pathogen to humans. These are termed zoonoses. Nonliving: includes soil and water Explain different methods of disease transmission; contact transmission (direct, indirect, droplet),vehicle transmission (waterborne, airborne), mechanical transmission (by vectors), and biological transmission (by vectors). Direct: requires close association between infected and susceptible host Indirect: spread by fomites Droplet: transmission via airborne droplets (that travel less than 1 meter) Vehicle: via air, water (travels more than 1 meter) or food Vector: arthropods, especially fleas, ticks, and mosquitoes Mechanical transmission: arthropod carries pathogen on feet Biological transmission: pathogen reproduces in vector Be able to define the following terms associated with disease progression; acute, chronic, and latent diseases, local, systemic, and focal infections, sepsis, communicable, contagious, and noncommunicable infections. ● Acute disease: symptoms develop rapidly (food poisoning) ● Chronic disease: disease develops slowly (tuberculosis) ● Latent disease: disease with a period of no symptoms when the causative agent is inactive (shingles) ● Local infection: pathogens are limited to a small area of the body ● Systemic infection: an infection throughout the body ● Sepsis: toxic inflammatory condition caused by spread of microbes throughout the body, especially bacteria or their toxins. ● Communicable disease: a disease that is spread from one host to another ● Contagious disease: a disease that is easily spread from one host to another ● Noncommunicable disease: a disease that is not transmitted from one host to another The difference between symptoms and signs. ● Symptoms: subjective characteristics of disease felt only by the patient ● Signs: objective manifestations of disease observed or measured by others What is epidemiology What is prevalence and incidence of a disease ● Epidemiology: the study of occurrence and transmission of disease in a population ● Incidence: # of new cases during a specific time period ● Prevalence: # of cases total at a given time Be able to define endemic, sporadic, epidemic, and pandemic. ● Endemic: disease always present at normal range ● Sporadic ­ Not normally present ­ Rarely occurs ● Epidemic ­ Not normally present ­ Large # of cases in one region ● Pandemic ­ Not normally present ­ Large # of cases in several regions What is the difference between morbidity and mortality Mortality: deaths from notifiable diseases Morbidity: incidence of a specific notable disease Define health­care associated infections and explain the interacting factors that result in nosocomial infections. How can nosocomial infections be prevented ● Presence of microorganisms in hospital environment ● Immunocompromised patients ● Transmission of pathogens between staff and patients and among patients Infections ● Urinary tract infections ● Surgical site infections ● Lower respiratory infections ● Cutaneous infections How they can be prevented ● Handwashing ● Limiting use of catheters/IVs ● Limiting use of broad spectrum antibiotics Chapter 16 What are the defining properties of innate immunity First line of defense ● Intact skin ● Mucous membranes and their secretions ● Normal microbiota Second line of defense ● Phagocytes, such as neutrophils, eosinophils, dendritic cells, and macrophages ● Inflammation ● Fever ● Antimicrobial substances

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Chapter 9.1, Problem 4E is Solved
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Textbook: Statistics for Engineers and Scientists
Edition: 4
Author: William Navidi
ISBN: 9780073401331

The answer to “The antibiotic gentamicin sulphate is often blended with acrylic bone cement to help prevent infection following joint replacement surgery. The article “Incorporation of Large Amounts of Gentamicin Sulphate Into Acrylic Bone Cement: Effect on Handling and Mechanical Properties, Antibiotic Release, and Biofilm Formation” (N. Dunne, P. McAfee, et al., Journal of Engineering in Medicine, 2008:355-365) presents a study of the effect of the amount of antibiotic added on various properties of the cement. Following are measurements of the setting time of the cement, for six levels of antibiotic amount, and three replications per level. The measurements are consistent with means and standard deviations presented in the article. a. Construct an ANOVA table. You may give a range for the P-value.________________b. Can you conclude that there are differences among the mean setting times?” is broken down into a number of easy to follow steps, and 132 words. This full solution covers the following key subjects: cement, antibiotic, setting, amount, properties. This expansive textbook survival guide covers 153 chapters, and 2440 solutions. Since the solution to 4E from 9.1 chapter was answered, more than 487 students have viewed the full step-by-step answer. This textbook survival guide was created for the textbook: Statistics for Engineers and Scientists , edition: 4. Statistics for Engineers and Scientists was written by and is associated to the ISBN: 9780073401331. The full step-by-step solution to problem: 4E from chapter: 9.1 was answered by , our top Statistics solution expert on 06/28/17, 11:15AM.

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The antibiotic gentamicin sulphate is often blended with