Propose a mechanism for the hydrolysis of N,N-dimethylacetamide
(a) under basic conditions.
(b) under acidic conditions.
(a) The mechanism for the hydrolysis of N, N- dimethyl acetamide under basic conditions is as follows:
This mechanism takes place in three steps. 1) Addition of the nucleophile (2) Elimination of the leaving group and (3) Proton transfer
Step 1: Addition of nucleophile:
Base attacks on the carbonyl carbon to form a tetrahedral intermediate.