Solution Found!
Show how the following products might be synthesized from
Chapter 16, Problem 56P(choose chapter or problem)
Show how the following products might be synthesized from suitable Michael donors and
Acceptors.
Questions & Answers
QUESTION:
Show how the following products might be synthesized from suitable Michael donors and
Acceptors.
ANSWER:
Solution 56P
(a)
The given compound is shown below:
In Michael addition product, a new bond is formed at carbon atom. To obtain Michael acceptor and Michael donor, break the bond. This is shown below:
Synthesize the given compound is as follows:
In step-I, the nucleophile attacks at electrophilic carbon atom to form enolate ion.
In step-II, the enolate ion is protonated and followed by keto-enol tautomerization to form target product.
(b)
The given compound is shown below:
In Michael addition product, a new bond is formed at carbon atom. To obtain Michael acceptor and Michael donor, break the bond. This is shown below:
Synthesize the given compound is as follows:
In step-I, the nucleophile attacks at electrophilic carbon atom to form enolate ion and followed by protonation to form ethyl 2-acetyl-4-cyanobutanoate.
Ethyl 2-acetyl-4-cyanobutanoate undergoes hydrolysis and decarboxylation to form target product.