What class of molecules is primarily responsible for differentiation? What evidence supports your answer?
Membrane Proteins: Integral membrane proteins are translated in the membrane the only difference is they have a transmembrane domain Transmembrane Domain: part of the protein that spans the membrane Transmembrane protein you would look at the hydrophobic-ness if you find there is 20-30 amino acids that are hydrophobic or have non-polar side chains you can predict that it is a transmembrane protein that would be a happy perfect protein to be embedded in the plasma membrane. Translated into the ER but they are going to pause during there translation and move into the membrane co-transnationally Form Alpha-helix so all peptide hydrogen bonds are going to be buried in helix so they won’t form contact with hydrophobic lipid and protein will remain in the ER. Goes in