In ttrl'ists 67- lO.for the column splllt of eaclr matrix. find a g~nullli11g set cofl/aining exacrlv the 1111111bu of ecrors specified. ctors - I 0 -2 6
March 7, 2016 VI. Mutation A. Types B. Methods of Detection C. Rate D. Some causes VII. Mutations as a tool for Biochemical pathways A. Garrod-Inborn Errors of Metabolism B. Beadle and Tatum “One Gene-One Enzyme” C. Prototrophs vs Autotrophs D. Pathway Interpretation Genes don’t act independently Genetics is study of abnormalities ! Garrod’s Classic: Inborn errors of metabolism ! Met+ is an auxotroph (nutritional mutation) prototroph - the normal allele (Met+) Prototroph (normal) mutations that lead to nutritional deficiencies auxotrophs “one genes, one enzyme” hypothesis later refined to “One gene, one polypeptide” hypothesis March 9, 2016 VII. Mutations as a tool for Biochemical Pathways A. Garrod - Inborn Errors of Metabolism B. Beadle and Tatum “One
