At the top ofthe next column are the amino acid sequences

Chapter 0, Problem 7

(choose chapter or problem)

At the top ofthe next column are the amino acid sequences (using the single-letter code; see Figure 5.17) offour short segments ofthe FOXP2 protein from six spedes: chimpanzee, orangutan, gorilla, rhesus macaque, mouse, and human. These segments contain all ofthe amino acid differencesbehl-'een the FOXP2 proteins ofthese species.ATETI.. PK5S0..T55TT NARRO2. ATE TI. .. PKSS E...TSSTT. .. NAR RO3. ATETI.. PKSSO...TSSTT, .NARRO4. ATETI.. PKSSO..TSSNT .SARRO5 ATETI.. PK5S0 ..T5STT NARRO6. VTETI.. PKSSO ..TSSTT, .NARRO Use a highlighter to color any amino acid that varies amongthe species. (Color that amino acid in all sequences.) Thenanswer the following questions.a. The chimpanzee, gorilla, and rhesus macaque (C, G, R)sequences are identical. Which lines correspond to thosesequences?b. The human sequence differs from that ofthe C, G, Rspecies at two amino acids. \Vhich line corresponds to thehuman sequence? Underline the two differences.c. The orangutan sequence differs from the C, G, R sequenceat one amino acid (having valine instead of alanine) andfrom the human sequence at three amino acids. Which linecorresponds to the orangutan sequence?d. How many amino acid differences are there between themouse and the C, G, R species? Circle the amino acid{s)that differ(s) in the mouse. How many amino aciddifferences are there between the mouse and the human?Draw a square around the amino acid{s) that differ{s) inthe mouse.e. Primates and rodents diverged between 60 and 100million years ago, and chimpanzees and humans divergedabout 6 million years ago. Knowing that, what can youconclude by comparing the amino acid differencesbetween the mouse and the C, G, R species with thedifferences between the human and the C, G, R species?