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An article in Nature Genetics [“Treatment-specific Changes
Chapter 6, Problem 81E(choose chapter or problem)
An article in Nature Genetics [“Treatment-specii c Changes in Gene Expression Discriminate in Vivo Drug Response in Human Leukemia Cells” (2003, Vol. 34(1), pp. 85–90)] studied gene expression as a function of treatments for leukemia. One group received a high dose of the drug, while the control group received no treatment. Expression data (measures of gene activity) from one gene are shown in Table 6E.1. Construct a box plot for each group of patients. Write an interpretation to compare the information in these plots.
TABLE. 6E.1 Gene Expression
\(\begin{array}{|r|c|c|c|}
\hline \text { High Dose } & \text { Control } & \text { Control } & \text { Control } \\
\hline 16.1 & 297.1 & 25.1 & 131.1 \\
\hline 134.9 & 491.8 & 820.1 & 166.5 \\
\hline 52.7 & 1332.9 & 82.5 & 2258.4 \\
\hline 14.4 & 1172 & 713.9 & 497.5 \\
\hline 124.3 & 1482.7 & 785.6 & 263.4 \\
\hline 99 & 335.4 & 114 & 252.3 \\
\hline 24.3 & 528.9 & 31.9 & 351.4 \\
\hline 16.3 & 24.1 & 86.3 & 678.9 \\
\hline 15.2 & 545.2 & 646.6 & 3010.2 \\
\hline 47.7 & 92.9 & 169.9 & 67.1 \\
\hline 12.9 & 337.1 & 20.2 & 318.2 \\
\hline 72.7 & 102.3 & 280.2 & 2476.4 \\
\hline 126.7 & 255.1 & 194.2 & 181.4 \\
\hline 46.4 & 100.5 & 408.4 & 2081.5 \\
\hline 60.3 & 159.9 & 155.5 & 424.3 \\
\hline 23.5 & 168 & 864.6 & 188.1 \\
\hline 43.6 & 95.2 & 355.4 & 563 \\
\hline 79.4 & 132.5 & 634 & 149.1 \\
\hline 38 & 442.6 & 2029.9 & 2122.9 \\
\hline 58.2 & 15.8 & 362.1 & 1295.9 \\
\hline 26.5 & 175.6 & & \\
\hline
\end{array}\)
Questions & Answers
QUESTION:
An article in Nature Genetics [“Treatment-specii c Changes in Gene Expression Discriminate in Vivo Drug Response in Human Leukemia Cells” (2003, Vol. 34(1), pp. 85–90)] studied gene expression as a function of treatments for leukemia. One group received a high dose of the drug, while the control group received no treatment. Expression data (measures of gene activity) from one gene are shown in Table 6E.1. Construct a box plot for each group of patients. Write an interpretation to compare the information in these plots.
TABLE. 6E.1 Gene Expression
\(\begin{array}{|r|c|c|c|}
\hline \text { High Dose } & \text { Control } & \text { Control } & \text { Control } \\
\hline 16.1 & 297.1 & 25.1 & 131.1 \\
\hline 134.9 & 491.8 & 820.1 & 166.5 \\
\hline 52.7 & 1332.9 & 82.5 & 2258.4 \\
\hline 14.4 & 1172 & 713.9 & 497.5 \\
\hline 124.3 & 1482.7 & 785.6 & 263.4 \\
\hline 99 & 335.4 & 114 & 252.3 \\
\hline 24.3 & 528.9 & 31.9 & 351.4 \\
\hline 16.3 & 24.1 & 86.3 & 678.9 \\
\hline 15.2 & 545.2 & 646.6 & 3010.2 \\
\hline 47.7 & 92.9 & 169.9 & 67.1 \\
\hline 12.9 & 337.1 & 20.2 & 318.2 \\
\hline 72.7 & 102.3 & 280.2 & 2476.4 \\
\hline 126.7 & 255.1 & 194.2 & 181.4 \\
\hline 46.4 & 100.5 & 408.4 & 2081.5 \\
\hline 60.3 & 159.9 & 155.5 & 424.3 \\
\hline 23.5 & 168 & 864.6 & 188.1 \\
\hline 43.6 & 95.2 & 355.4 & 563 \\
\hline 79.4 & 132.5 & 634 & 149.1 \\
\hline 38 & 442.6 & 2029.9 & 2122.9 \\
\hline 58.2 & 15.8 & 362.1 & 1295.9 \\
\hline 26.5 & 175.6 & & \\
\hline
\end{array}\)
Step 1 of 3
A boxplot, also known as a box-and-whisker plot, is a graphical representation of the distribution of a dataset. It provides a summary of the central tendency, dispersion, and skewness of the data. Boxplots are especially useful for comparing the distribution of different groups or datasets.