Aprobarbital, a barbiturate once used in treating insomnia, is synthesized in three

Chapter 22, Problem 22

(choose chapter or problem)

Aprobarbital, a barbiturate once used in treating insomnia, is synthesized in three steps from diethyl malonate. Show how you would synthesize the necessary dialkylated intermediate, and then propose a mechanism for the reaction of this intermediate with urea to give aprobarbital.

Equation Transcription:

Text Transcription:

EtO_2C

CO_2Et

H_2N-C-NH_2

Na+-OEt

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