Aprobarbital, a barbiturate once used in treating insomnia, is synthesized in three
Chapter 22, Problem 22(choose chapter or problem)
Aprobarbital, a barbiturate once used in treating insomnia, is synthesized in three steps from diethyl malonate. Show how you would synthesize the necessary dialkylated intermediate, and then propose a mechanism for the reaction of this intermediate with urea to give aprobarbital.
Equation Transcription:
Text Transcription:
EtO_2C
CO_2Et
H_2N-C-NH_2
Na+-OEt
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