One of the steps in the biosynthesis of uridine

Chapter 28, Problem 28

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One of the steps in the biosynthesis of uridine monophosphate is the reaction of aspartate with carbamoyl phosphate to give carbamoyl aspartate followed by cyclization to form dihydroorotate. Propose mechanisms for both steps. Carbamoyl Dihydroorotate aspartate Carbamoyl phosphate Aspartate Pi H2O + CO2 CO2 H3N + H CO2 O O N N H H H O O H O H2N CO2 H

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