Valganciclovir, marketed as Valcyte, is an antiviral agent used for the treatment of
Chapter 28, Problem 28(choose chapter or problem)
Valganciclovir, marketed as Valcyte, is an antiviral agent used for the treatment of cytomegalovirus. Called a prodrug, valganciclovir is inactive by itself but is rapidly converted in the intestine by hydrolysis of its ester bond to produce an active drug, called ganciclovir, along with an amino acid. N N Valganciclovir O O NH2 NH2 N N H O O H OH (a) What amino acid is produced by hydrolysis of the ester bond in valganciclovir? (b) What is the structure of ganciclovir? (c) What atoms present in the nucleotide deoxyguanine are missing from ganciclovir? (d) What role do the atoms missing from deoxyguanine play in DNA replication? (e) How might valganciclovir interfere with DNA synthesis?
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