An article in Nature Genetics (2003, Vol. 34(1), pp. 8590) Treatment-specific changes in

Chapter 13, Problem 13-50

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An article in Nature Genetics (2003, Vol. 34(1), pp. 8590) Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells studied gene expression as a function of different treatments for leukemia. Three treatment groups are: mercaptopurine a 5 (MP) only; low-dose methotrexate (LDMTX) and MP; and high-dose methotrexate (HDMTX) and MP. Each group contained ten subjects. The responses from a specific gene are shown in Table 13-18. (a) Check the normality of the data. Can we assume these samples are from normal populations? (b) Take the logarithm of the raw data and check the normality of the transformed data. Is there evidence to support the claim that the treatment means differ for the transformed data? Use (c) Analyze the residuals from the transformed data and comment on model adequacy.

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