Coumarin and its derivatives exhibit a broad array of industrial applications

Chapter 2, Problem 2.69

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Coumarin and its derivatives exhibit a broad array of industrial applications, including, but not limited to, cosmetics, food preservatives, and fluorescent laser dyes. Some derivatives of coumarin, such as warfarin, exhibit antithrombic activity and are currently used as blood thinners (to prevent the formation of potentially fatal blood clots). Identify how you might use IR spectroscopy to monitor the following reaction, in which compound 1 is converted into a coumarin derivative (compound 2). Describe at least three different signals that you could analyze to confirm the transformation of 1 to 2 (J. Chem. Ed. 2006, 83, 287289). 2 1 N OH H O O O O O O N

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