Acid-catalyzed transesterification and Fischer esterification take place by nearly
Chapter 21, Problem 21-46(choose chapter or problem)
Acid-catalyzed transesterification and Fischer esterification take place by nearly identical mechanisms. Transesterification can also take place by a base-catalyzed mechanism, but all attempts at base-catalyzed Fischer esterification (using \(^{-}OR\)″, for example) seem doomed to failure. Explain why Fischer esterification cannot be catalyzed by base.
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