Quinolines (Section 25-7) are heterocycles that are widely used in medicinal chemistry
Chapter 25, Problem 53(choose chapter or problem)
Quinolines (Section 25-7) are heterocycles that are widely used in medicinal chemistry becauseof the diversity of biological activity including anticancer utility that their derivatives display.A short synthesis of 3-acyldihydroquinolines (which may be converted into 3-acylquinolinesby mild oxidation) is shown below. Propose a mechanism for this process. (Hint: ReviewSection 18-10.) OOBase catalystHONHNH2CH3 CH3
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