To calculate the isoelectric point of amino acids having other ionizable functional
Chapter 28, Problem 28.35(choose chapter or problem)
To calculate the isoelectric point of amino acids having other ionizable functional groups, we must also take into account the pKa of the additional functional group in the side chain. For an acidic amino acid (one with an additional acidic For a basic amino acid (one with an additional basic NH OH group): group): pI = pKa (-COOH) + pKa (second COOH) pI = pKa (-NH3 + ) + pKa (side chain NH) 2 2 a. Indicate which pKa values must be used to calculate the pI of each of the following amino acids: [1] glutamic acid; [2] lysine; [3] arginine. b. In general, how does the pI of an acidic amino acid compare to that of a neutral amino acid? c. In general, how does the pI of a basic amino acid compare to the pI of a neutral amino acid?
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