When NAD+ becomes NADH, the coenzyme has been ________. a. reduced b. oxidized c

Cell Bio May 10  E27-1  20-39 o Age-adjusted cancer death rates o Lung is HIGH in males  20-43 o Imatinib(Gleevec) blocks activity of Bcr-Abl proteins and halts chronic mylogenous leukemia  Nib- small molecules o Imantinib occupies the ATP binding pocket of the tyrosine kinase domain o Drug imatinib (Gleevec blocks the acitivity of oncogenic proteins and halts certain cancers  20-44 o Anti-cancer drugs target Ras-MAP-kinase signaling pathway o Mab- antibody based drugs o Nib- small molecule based drugs  20-46 o Multidrug treatments can be more effective than sequential treatment o Tumor cells are hypermutable, single drug treat treatment that are given sequentially often allow for selection of mutant cell clones that are resistant to both drugs Programmed cell death A. Part of normal development program B. Molecular mechanisms  E27-2  18-1 o Necrosis- swelling and rupture of cells following injury o Apoptosis- dismantling of the internal contents of the cell (fragmentation of DNA and organnels)  18-2 o Cell death inbetween digits  E27-3 o Apoposis to help eliminate the tail during metamorphosis  E27-4  18-3 o Caspase activitaion during apop o Initiator and executioner  E27-5  18-4 o DNA fragm