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Here we investigate the molecular basis for the observation that the hydrolysis of ATP

Physical Chemistry | 8th Edition | ISBN: 9780716787594 | Authors: Peter Atkins, Julio de Paula ISBN: 9780716787594 348

Solution for problem 7.28 Chapter 7

Physical Chemistry | 8th Edition

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Physical Chemistry | 8th Edition | ISBN: 9780716787594 | Authors: Peter Atkins, Julio de Paula

Physical Chemistry | 8th Edition

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Problem 7.28

Here we investigate the molecular basis for the observation that the hydrolysis of ATP is exergonic at pH = 7.0 and 310 K. (a) It is thought that the exergonicity of ATP hydrolysis is due in part to the fact that the standard entropies of hydrolysis of polyphosphates are positive. Why would an increase in entropy accompany the hydrolysis of a triphosphate group into a diphosphate and a phosphate group? (b) Under identical conditions, the Gibbs energies of hydrolysis of H4ATP and MgATP2, a complex between the Mg2+ ion and ATP4, are less negative than the Gibbs energy of hydrolysis of ATP4. This observation has been used to support the hypothesis that electrostatic repulsion between adjacent phosphate groups is a factor that controls the exergonicity of ATP hydrolysis. Provide a rationale for the hypothesis and discuss how the experimental evidence supports it. Do these electrostatic effects contribute to the rH or rS terms that determine the exergonicity of the reaction? Hint. In the MgATP2complex, the Mg2+ ion and ATP4 anion form two bonds: one that involves a negatively charged oxygen belonging to the terminal phosphate group of ATP4 and another that involves a negatively charged oxygen belonging to the phosphate group adjacent to the terminal phosphate group of ATP4.

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Chapter 7, Problem 7.28 is Solved
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Textbook: Physical Chemistry
Edition: 8
Author: Peter Atkins, Julio de Paula
ISBN: 9780716787594

This textbook survival guide was created for the textbook: Physical Chemistry , edition: 8. Since the solution to 7.28 from 7 chapter was answered, more than 213 students have viewed the full step-by-step answer. The answer to “Here we investigate the molecular basis for the observation that the hydrolysis of ATP is exergonic at pH = 7.0 and 310 K. (a) It is thought that the exergonicity of ATP hydrolysis is due in part to the fact that the standard entropies of hydrolysis of polyphosphates are positive. Why would an increase in entropy accompany the hydrolysis of a triphosphate group into a diphosphate and a phosphate group? (b) Under identical conditions, the Gibbs energies of hydrolysis of H4ATP and MgATP2, a complex between the Mg2+ ion and ATP4, are less negative than the Gibbs energy of hydrolysis of ATP4. This observation has been used to support the hypothesis that electrostatic repulsion between adjacent phosphate groups is a factor that controls the exergonicity of ATP hydrolysis. Provide a rationale for the hypothesis and discuss how the experimental evidence supports it. Do these electrostatic effects contribute to the rH or rS terms that determine the exergonicity of the reaction? Hint. In the MgATP2complex, the Mg2+ ion and ATP4 anion form two bonds: one that involves a negatively charged oxygen belonging to the terminal phosphate group of ATP4 and another that involves a negatively charged oxygen belonging to the phosphate group adjacent to the terminal phosphate group of ATP4.” is broken down into a number of easy to follow steps, and 209 words. This full solution covers the following key subjects: . This expansive textbook survival guide covers 25 chapters, and 1736 solutions. The full step-by-step solution to problem: 7.28 from chapter: 7 was answered by , our top Chemistry solution expert on 03/08/18, 07:47PM. Physical Chemistry was written by and is associated to the ISBN: 9780716787594.

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