Solution Found!
The presence of bacterial lipopolysaccharide (LPS) in the blood is a major cause of
Chapter 43, Problem 11(choose chapter or problem)
The presence of bacterial lipopolysaccharide (LPS) in the blood is a major cause of septic shock. Suppose you have available purified LPS and several strains of mice, each with a mutation that inactivates a particular TLR gene. How might you use these mice to test the feasibility of treating septic shock with a drug that blocks TLR signaling?
Questions & Answers
QUESTION:
The presence of bacterial lipopolysaccharide (LPS) in the blood is a major cause of septic shock. Suppose you have available purified LPS and several strains of mice, each with a mutation that inactivates a particular TLR gene. How might you use these mice to test the feasibility of treating septic shock with a drug that blocks TLR signaling?
ANSWER:1. Inject the mice with the mutated TLR gene with LPS to observe the effects.
2. Inject the same mice with the drug that blocks TLR signaling along with LPS the observed the effects.
3. Compare the effects from step 1 and step 2 in the mice with mutated TLR gene.