The protein hemoglobin (Hb) transports O2 in mammalian blood.Each Hb can bind 4 O2

Chapter 20, Problem 15.100

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The protein hemoglobin (Hb) transports O2 in mammalian blood.Each Hb can bind 4 O2 molecules.The equilibrium constant for the O2-binding reaction is higher in fetal hemoglobin than in adult hemoglobin. In discussing protein oxygenbinding capacity, biochemists use a measure called the P50 value,defined as the partial pressure of oxygen at which 50% of the protein is saturated.Fetal hemoglobin has a P50 value of 19 torr, and adult hemoglobin has a P50 value of 26.8 torr. Use these data to estimate how much larger Kc is for the aqueous reaction 4 O2(g) + Hb(aq) [Hb(O2)4(aq)].

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