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Propose a mechanism for the following transformation: O

Chapter 9, Problem 9.63

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QUESTION:

Propose a mechanism for the following transformation: O MeO OH MeOH [H2SO4]

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QUESTION:

Propose a mechanism for the following transformation: O MeO OH MeOH [H2SO4]

ANSWER:

Step 1 of 3

The acid-catalyzed opening of this epoxide begins with the protonation of the epoxide oxygen. The proton probably comes from a protonated MeOH molecule since the  of  is so low that it will not exist in any large amount in solution.

     

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