The reaction of a nitrile with an alcohol in the presence
Chapter 16, Problem 90(choose chapter or problem)
The reaction of a nitrile with an alcohol in the presence of a strong acid forms an N-substituted amide. This reaction, known as the Ritter reaction , does not work with primary alcohols. RC N R + OH C O HCl the Ritter reaction R NHR a. Propose a mechanism for the Ritter reaction. b. Why does the Ritter reaction not work with primary alcohols? c. How does the Ritter reaction differ from the acid-catalyzed hydrolysis of a nitrile to form an amide?
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