During the first total synthesis of chelidonine, a

Chapter 17, Problem 17.74

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During the first total synthesis of chelidonine, a cytotoxic natural product isolated from the root of Chelidonium majus, the investigators used only heat to achieve the following transformation (J. Am. Chem. Soc. 1971, 93, 38363837). Propose a plausible mechanism for this thermal cyclization process. O O N R O O O O N O O R 120C

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