a. Explain why the alkyl halide shown here reacts much

Chapter 23, Problem 45

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a. Explain why the alkyl halide shown here reacts much more rapidly with guanine than does a primary alkyl halide (such as pentyl chloride). Cl Cl H2N N R N N O + 2 HN + H2N NH2 N R N N N O O + N R N Cl Cl HN NH N N b. The alkyl halide can react with two guanines, each in a different DNA chain, thereby cross-linking the chains. Propose a mechanism for the cross-linking reaction.

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