Triosephosphate isomerase (TIM) catalyzes the conversion
Chapter 23, Problem 46(choose chapter or problem)
Triosephosphate isomerase (TIM) catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate. The enzymes catalytic groups are Glu 165 and His 95. In the i rst step of the reaction, these catalytic groups function as a general-base and a general-acid catalyst, respectively. Propose a mechanism for the reaction.
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